The main cause of periodontal disease is bacterial plaque, a sticky, colorless film that forms on your teeth. Bacterial plaque isn’t the only cause though. Other factors, like the following can also affect the health of your gums like Smoking or Tobacco Use, Genetics, Pregnancy and Puberty, Stress, Medications, Clenching or Grinding Your Teeth, Diabetes, Poor Nutrition and other Systemic Diseases that interfere with the body's immune system.